Hypothermic Kidney Perfusion Platform
Fully integrated kidney perfusion system with RM4Ⓡ pump + DCX cassette + Waters IGLⓇ Pulsatile Preservation Solution, and remote monitoring IGL-APP all from a single provider.
Clinically proven technology
RM4Ⓡ inherits the Waters Hypothermic Machine Perfusion technology, which is beneficial to marginal donor kidneys, leading to more favorable immediate graft function and delayed graft function compared to static cold storage. Immediate graft function is defined by serum creatinine falls of more than 20% in the first 24 hours post-transplant. Delayed graft function is defined as the need for dialysis within 7 days of transplantation.
Immediate function rate (%) p=0.057
Light JA Clinical Transplantation June 1996; 10(3) 233-6
Delayed Graft function (%) p=0.002
Stratta RJ J American College of Surgeons May 2007; 204(5) : 873-82 ; discussion 882-4
Waters Machine Perfusion
Static Cold Storage
RM4®
RM4Ⓡ is a renal perfusion system, designed to support monitoring of either one or two kidneys. The RM4Ⓡ system provides controlled kidney perfusion of hypothermic solution, monitor, display, trend, export and save perfusion parameters, including perfusate flow, temperature, pressure, and renal resistance, as well as the organ identifiers.
RM4Ⓡ Kidney Perfusion System is FDA cleared. DCX organ cassette has received FDA 510(k) clearance.
IGL-App: Remote monitoring of organ perfusion status.
Specifications
- 2-kidney capacity in same cassette
- Organ immersion in preservation solution
- Secure locking lid
- Active oxygenation inside the cassette
- Linear pump delivers true pulsatile pressure
- External chiller connection (optional)
- Graphical user interface
- Detachable, sealed ice tank
- Wi-fi connectivity & IGL-app
Overview
The gold standard in kidney preservation technology
RM4Ⓡ combines pulsatile hypothermic machine perfusion and integrated active oxygenation to optimize donor kidney viability for 24 hours.
Waters IGL® Pulsatile Perfusion Solution (PPS)
Waters IGL® Pulsatile Perfusion Solution is a clear to slightly yellow solution for the in-vitro flushing and temporary continuous perfusion preservation of explanted kidneys.
Waters IGL® Pulsatile Perfusion Solution is intended to be used for flushing and continuous hypothermic machine perfusion of kidneys at the time of their removal from the donor in preparation for storage, transportation, and eventual transplantation into a recipient.
This solution is consistent with an extracellular solution based on its sodium/potassium ratio. This solution has a calculated osmolality of 300 mOsm/kg, a sodium concentration of 100 mmol/L, a potassium concentration of 25 mmol/L and a pH of 7.4 at 20°C/68°F.
Images are for illustration only. Product appearance may differ slightly depending on packaging, or product variant.
View bag label
| Ingredients | Amount |
|---|---|
| Adenine (free base) | 0.68 g/L |
| Calcium Chloride (dihydrate) | 0.068 g/L |
| Dextrose (+) | 1.80 g/L |
| Glutathione (reduced) | 0.92 g/L |
| HEPES (free acid) | 2.38 g/L |
| Hydroxyethyl Starch | 50.0 g/L |
| Magnesium Gluconate (anhydrous) | 1.13 g/L |
| Mannitol | 5.4 g/L |
| Potassium Phosphate (monobasic) | 3.4 g/L |
| Ribose, D(-) | 0.75 g/L |
| Sodium Gluconate | 17.45 g/L |
| Sodium Hydroxide | 0.70 g/L |
| Sterile Water for injection | qs 1 litre |
Physiological system
Pulsatile arterial pressure and oxygenation of the perfusate to simulate human physiology
Dual perfusion
An obvious cost-saving and convenient procedure for centers with any number of transplants
Convenient interface
Equipped with a large touchscreen interface to guide the user, minimizing setup and training time
