CELSIOR® COLD STORAGE SOLUTION
Celsior® Cold Storage Solution is a sterile, non-pyrogenic solution for heart preservation. It is intended for flushing and cold storage of hearts at the time of their removal from the donor in preparation for storage, transportation, and eventual transplantation into a recipient. Administration of Celsior® cools the organ, and therefor reduces its metabolic requirements and associated energy consumption.
Superior outcomes
Ready to use Solution
Optimal Storage
SPECIALLY FORMULATED FOR PRESERVATION OF HEART
The Celsior® solution is slightly acidic (approximate pH 7.3 at 20°C), slightly hypertonic (approximate calculated osmolarity 320-360 mOsmol/L) with low viscosity (1.15 cSt), and has a high buffering capacity (acidic approximately 11 mmol, alkaline approximately 7 mmol).
- Celsior® guarantees the antioxidant action, with permanently reduced glutathione, histidine, lactobionate and mannitol.
- With a low potassium, low calcium and high magnesium content, Celsior® can be used for the heart organs, protecting against calcium overload.
- Celsior®’s composition of impermeants helps to avoid the swelling of cells during cold ischaemic storage.
- Celsior® contains histidine, which has an excellent capacity for hydrogen ion buffering¹ thereby protecting grafts from acidosis.
- Celsior® contains substrates that help the production of energy in anaerobic conditions.
1 Menasche P, Termignon JL, Pradier F, et al. Experimental evaluation of Celsior, a new heart preservation solution. Eur J Cardiothorac Surg 1994;8(4):207-13.
BETTER OUTCOMES COMPARED TO HTK
Celsior® is associated with superior outcomes in graft function vs HTK.
Clinical studies have shown that Celsior® is associated with a reduced incidence of graft rejection and a higher rate of spontaneous sinus rhythm following heart transplantation compared to HTK ².
2 Garlicki M. May preservation solution affect the incidence of graft vasculopathy in transplanted heart? Ann Transplant 2003;8(1):19-24.